INVERSE: Non-Invasive Detection of Ventricular Arrhythmogenic Substrates

Project Coordinator: Assoc. Prof. Dr. Yeşim Serinağaoğlu Doğrusöz
Project Type: TUBITAK Bosphorus 2509, TÜBİTAK – the French Ministry of Foreign Affairs Bilateral Cooperation Project
Project Budget: To be Announced
Project Duration: 24 Months
Project Start Date: 01 June 2022
Funded Personnel: 1 PhD Student (Full-Time), 1 MSc Student (Full-Time)

Project Summary: Ventricular arrhythmias are a major cause of sudden cardiac death (SCD), which accounts for about half of cardiac mortality. INVERSE will focus on patients with an abnormal chronic substrate, which is largely underestimated and not addressed by current guidelines for preventive therapy. The electrical measurements performed with ECGI in this project will allow for a detailed non-invasive characterization of th e specific features for hearts with an arrhythmogenic substrate leading to SCD. Non-invasive ECGI detection of arrhythmogenic substrates will improve SCD risk stratification and offer preventive treatment of high-risk individuals by defibrillators, interventions or anti-arrhythmic therapies.

Ex-vivo torso tank recordings utilizing pig hearts, and clinical data from patients with primary electrical anomalies, who arrive for treatment at the Hôpital Haut Lévèque (Bordeaux, France), will be used for evaluating the ECGI methods. Geometric models will be generated from medical images, then subject-specific forward matrices will be computed. Inverse problem will be solved using novel ECGI methods such as Lp norm-based methods, spatio-temporal regularization, sparse representations and learning-based methods. Results will be evaluated qualitatively and quantitatively by comparing with the ground truth obtained from the experiments.

Online progress meetings will be organized every month with the members involved in this period to discuss potential issues and short-term experimentations. Five visits for general meetings will be organized with all the members involved in the project to discuss global progress, strategic decisions and future directions.